glutamic acid decarboxylase การใช้

• GABA is synthesized in a single step from its precursor glutamate by glutamic acid decarboxylase.
• The molecule was effectively shaped for transportation into the brain, where it activated L-Glutamic acid decarboxylase, an enzyme.
• This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes.
• Another gene therapy of PD involved insertion of the glutamic acid decarboxylase ( GAD ) into the subthalamic nucleus.
• In the mouse, when the GAD gene is active, it expresses, or causes the cell to make, a protein called glutamic acid decarboxylase.
• High titers of autoantibodies to glutamic acid decarboxylase ( GAD ) are well documented in association with stiff person syndrome ( SPS ).
• Persons with LADA usually test positive for Glutamic acid decarboxylase antibodies, whereas in type 1 diabetes these antibodies are more commonly seen in adults rather than in children.
• It turns out that islet cells in his pancreas contain a protein, glutamic acid decarboxylase ( GAD ), that has the same amino acid sequence on its surface.
• Diseases include vitamin E deficiency, abetalipoproteinemia, cerebrotendinous xanthomatosis, Niemann Pick type C disease, Refsum's disease, glucose transporter type 1 deficiency, episodic ataxia type 2, gluten ataxia, glutamic acid decarboxylase ataxia.
• There have also been proposed vaccines for type I using glutamic acid decarboxylase ( GAD ), but these are currently not being tested by the pharmaceutical companies that have sublicensed the patents to them.
• DLX5 and DLX2 directly regulate expression of glutamic acid decarboxylase, the enzyme that produces the neurotransmitter GABA . Conclusive evidence of autism susceptibility due to novel sequence variants of these genes has yet to be clearly identified, however.
• Antibodies directed against glutamic acid decarboxylase ( GAD ) are increasingly found in patients with other symptoms indicative of central nervous system ( CNS ) dysfunction, such as ataxia, progressive encephalomyelitis with rigidity and myoclonus ( PERM ), limbic encephalitis, and epilepsy.
• Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of ?-aminobutyric acid ( GABA ), and impaired function of GABAergic neurons has been implicated in the pathogenesis of SPS . Autoantibodies to GAD might be the causative agent or a disease marker.
• The bilateral delivery of glutamic acid decarboxylase ( GAD ) by an adeno-associated viral vector into the subthalamic nucleus of patients between 30 and 75 years of age with advanced, progressive, levodopa-responsive Parkinson disease resulted in significant improvement over baseline during the course of a six-month study.
• In people with suspected ketosis-prone type 2 diabetes, determination of antibodies against glutamic acid decarboxylase and islet cells may aid in the decision whether to continue insulin administration long-term ( if antibodies are detected ), or whether to withdraw insulin and attempt treatment with oral medication as in type 2 diabetes.